Project Description

Porphobilinogen ( PBG )

Urine Porphobilinogen (PBG) is useful for the evaluation of neurologic and/or psychiatric symptoms to exclude acute porphyrias such as acute intermittant porphyria (AIP), veriegate porphyria and hereditary coproporphyria.

The method is based on a modified Mauzerall and Granick and is explained in more modern terms by Deacon.

After sample preparation the sample is measured on our UVIKON XS double beam UV/Vis spectrophotometer at 553nm. The results are normalised to creatinine concentration and reported as a ratio of amounts (micromoles of porphyrin / millimoles of creatinine).

  • Up to 20 samples per batch measured either sequentially or using an automatic cell changer
  • Sample number and or patient name can be entered
  • 553nm absorbance and PBG calculation (umol/l) automatically performed
  • Selectable PBG upper and lower concentration warning limits
  • Sample dilution taken into consideration for calculation
  • PBG / Creatinine ratio calculated (umol/mmol)